rhapontic rhubarb root extract drug interactions

A few studies have also been conducted using topical applications. Tan, W., J. Lu, M. Huang et al. Some laxatives can decrease potassium in the body. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. While some of these side effects like discolored urine are harmless, some others are mild. 1999;19(4):218-220. Pursuing basic and translational research across 9 programs and 100+ labs, Focusing on clinical cancer research and population health, Bridging the lab and the clinic through translational research, Fostering interdisciplinary collaborations between laboratory scientists and clinicians, Partnering with other academic and research institutions, Offering state-of-the-art resources for our researchers, Offering a curriculum with a focus on cancer, Connecting college seniors to future careers in biomedicine, 2023 Memorial Sloan Kettering Cancer Center, Human Oncology & Pathogenesis Program (HOPP), Gerstner Sloan Kettering Graduate School of Biomedical Sciences, High school & undergraduate summer programs, Integrative Medicine at Home Membership Program. Estrovera reduces the severity of menopausal symptoms. View abstract. View abstract. Cai, J., Xuan, Z. R., Wei, Y. P., Yang, H. B., and Wang, H. [Effects of perioperative administration of Rhubarb on acute inflammatory response in patients with gastric cancer]. Rhubarb is considered to be a stimulant laxative and is high in oxalates(37). Active Ingredients:Rhapontic Rhubarb Root Extract, Microcrystalline cellulose,, dicalcium phosphate, stearic acid, croscarmellose sodium, magnesium stearate Estroven Complete Menopause Relief Pros & Cons Pros May relief up to 12 symptoms of menopause by up to 60% according to the manufacturer Rhubarb might harm the liver. Is the ketogenic diet right for autoimmune conditions? Jiao, D. H., Ma, Y. H., Chen, S. J., Liu, C. T., Shu, H. N., and Chu, C. M. Resume of 400 cases of acute upper digestive tract bleeding treated by rhubarb alone. In vitro and in vivo data of the estrogenic actions of ERr, particularly those mediated by estrogen receptor- (ER), are reviewed. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Song, H., Wang, Z., and Zhang, F. [Investigation of urinary interleukin-6 level in chronic renal failure patients and the influence of Rheum palmatum in treating it]. Another main ingredient of Estroven is soy isoflavones. View abstract. The best part is no nausea or heart racing when I do flash!! Protects The Heart Save Image: Shutterstock Being a good source of fiber, rhubarb has shown to lower cholesterol levels. Rhubarb is a perennial herb, and the stalks are sometimes consumed as food. Health-related information changes frequently and therefore information contained on this Web site may be outdated, incomplete or incorrect. Chin Med J (Engl.) Clinical observation on 157 subjects of gonorrhea treated with rhubarb preparation. 1980;90(8):718-724. Kwan TH, Tong MK, Leung KT, et al. They contain substances called isoflavones, which are plant-based estrogens ("phytoestrogens"). Pharmacology 1980;20 Suppl 1:128-130. a plant-based extract of Siberian rhubarb. Arch Oral Biol 4-5-2006; View abstract. View abstract. Both Amberen and Estroven claim that their products relieve various symptoms associated with menopause, such as hot flashes and mood changes. Estroven does not mention side effects on their website. The special extract ERr 731 from the roots of rhapontic rhubarb has been regularly prescribed for women with menopausal symptoms since 1993. Zhang, W. L. [Treatment of hemorrhage of the upper gastro-intestinal tract with the Chinese drug hai huang san. Additional studies to confirm safety and efficacy are needed. Rhubarb is also used as a flavoring agent. A Study has proved the favorable effects of stearic acid[3]. View abstract. [Clinical study on niaodujing in treating chronic renal failure]. Acute renal failure has been associated with long-term anthraquinone use. Most reported clinical trials have been small and poorly designed, and in some studies, a number of different herbs were coadministered with rhubarb, making it difficult to evaluate which herb contributed to the outcomes. View abstract. Uchida, S., Ikari, N., Ohta, H., Niwa, M., Nonaka, G., Nishioka, I., and Ozaki, M. Inhibitory effects of condensed tannins on angiotensin converting enzyme. Zhong.Xi.Yi.Jie.He.Za Zhi. Kidney stones: Rhubarb contains a chemical that the body can convert into kidney stones. RxList does not provide medical advice, diagnosis or treatment. Our scientists pursue every aspect of cancer researchfrom exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. Uterine contractions. However, the molecular basis of its clinical effectiveness remains obscure. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as a medical advice. Clinical study on effect of shenlong oral liquid combined with radiotherapy in treating nasopharyngeal carcinoma. Xu, F. and Fu, H. M. [Qing-shen tiao-zhi tablet in the treatment of hyperlipemia in the middle and old aged]. Amberen claims that its product has no adverse side effects. There are many management options for menopause symptoms like lifestyle changes, hormone replacement therapy (HRT), and the use of menopause supplements. Chinese Journal of Nursing 1995;7(30):420-422. (Chinese Journal of Modern Developments in Traditional Medicine) 1990;10(3):150-152, 131-132. View abstract. Study suggest this is used for the capsules as it is biodegradable[2] and it is entirely natural. It has been consumed for centuries in Siberia and across Eastern Europe, often alongside Rhodiola, another adaptogen that hails from the same region. Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locator Tool Including 24 Hour, Pharmacies. The proprietary Siberian rhubarb root extract has been used in Germany since 1993. Biol Pharm Bull. Tseng, S. H., Lee, H. H., Chen, L. G., Wu, C. H., and Wang, C. C. Effects of three purgative decoctions on inflammatory mediators. Rhubarb can cause some side effects such as stomach and intestinal pain, watery diarrhea, and uterine contractions. [Chinese Journal of Integrated Traditional and Western Medicine] 1986;6(8):458-459, 451. Use of this Web site does not create an expressed or implied physician-patient relationship. Effects and mechanisms of emodin on cell death in human lung squamous cell carcinoma. Standardized rhapontic rhubarb extract (also called "false rhubarb" or "Siberian rhubarb") is easily found in a handful of supplements - usually marketed as "menopause relief" blends - here at home. Wu, C. X. It appears to have some benefits for the . In addition to rhaponticin, various other components of rhubarb have anti-inflammatory effects, such as emodin, rhein, chrysophanol, and aloe emodin. . You should talk with your health care provider for complete information about the risks and benefits of using this product. Chinese Journal of Modern Developments in Traditional Medicine 1987;7(1):21-3, 4. Significant overall clinical efficacy was demonstrated in the rhubarb intervention group compared with Western medicine controls (n = 788; relative risk [RR] = 1.27; P < 0.01); all trials had a relatively high risk of bias and the funnel plot indicated publication bias. Once you have taken the picture, save the image as a JPG, TIF, or PDF file. Jin, H. M. and Jiao, D. H. [Effect of jiang-zhi jian-fei yao on gastro-intestinal movement and adipose cell of abdominal wall]. View abstract. [Application and mechanism of radix et rhizoma rhei in treating diseases of the digestive system]. Research shows evidence for the effectiveness of this plant in treating menopause symptoms. By the end of the 19th century, it became clear that the particular medicinal characteristics of rhubarb were affected by conditions under which the roots grew, such as soil composition and climate.5, Rhubarb has been used medicinally in Europe since the 13th century. Lipid profiles were improved in the two experimental arms.22, Treating hypercholesterolemia in men with rhubarb stalk fiber for 4 weeks lowered serum total cholesterol and low-density lipoproteins (LDL), while high-density lipoproteins remained unchanged.26 In 103 patients with atherosclerosis randomized to receive the extract for 6 months, rhubarb extract improved the lipid profile in patients with chronic renal failure (CRF) compared with control.25 Individuals taking rhubarb reported decreased LDL compared with those taking placebo and compared with the pretreatment levels.27, The North American Menopause Society position statement for nonhormonal management of menopause-associated vasomotor symptoms (2015) states that although beneficial effects in overall symptoms have been reported with a commercial proprietary rhubarb extract preparation, more data are needed on both safety and efficacy of Siberian rhubarb (Rheum rhaponticum) for use in menopausal vasomotor symptoms (Level II).58, Large, randomized clinical trials are lacking. Rhapontic rhubarb is used for many of the same reasons as black cohosh, and it's the active ingredient in the popular menopause supplement Estroven. Iida, K., Hase, K., Shimomura, K., Sudo, S., Kadota, S., and Namba, T. Potent inhibitors of tyrosinase activity and melanin biosynthesis from Rheum officinale. In lab animals, compounds in rhubarb called anthraquinones reduced pain, inflammation, and some tumors. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. The constituents of R. officinale are similar to those of Chinese Rhubarb. View abstract. But, has anyone else had any unusual bleeding on this pill? Negative reviews mention adverse side effects from the product. Rhubarb extract 20 mg/kg daily administered for 6 weeks to patients undergoing radiation therapy for cancer resulted in a reduction in radiation-induced lung toxicity in a randomized clinical trial. Therefore there is much interest in finding safe, alternative treatments for hot flashes and other symptoms caused by menopause. Copyrights 2003-2023 All Rights Reserved. Hua Xi.Yi.Ke.Da.Xue.Xue.Bao. The dosage of ERr 731 (rhapontic rhubarb) is 1 tablet/day. Rhubarb is mainly used for digestive complaints such as diarrhea, constipation, heartburn, gastrointestinal (GI) bleeding, stomach pain, and preparation for GI diagnostic procedures. Singapore Med J 1996;37(6):645-651. Rhubarb stem, when taken in the form of food, is considered to be safe. Until recently, hormone replacement therapy (HRT) was the most common treatment for menopausal hot flashes. Treatment of menopausal symptoms by an extract from the roots of rhapontic rhubarb: the role of estrogen receptors. Chin J Integr Tradit West Med 2001;7(1):33-35. Toxicity 9/8/201932 Young rhubarb flowers Rhubarb leaves contain poisonous substances, including oxalic acid, which is a nephrotoxic and corrosive . A small amount of rhubarb may have adhered to the wall of the tracheobronchial tree, producing a localized area of oxalosis with accompanying necrosis.54 Consumption of rhubarb in patients with renal stones is not advised because of the oxalate content.13, The leaf blades, but not the stalks, of rhubarb contain enough oxalic acid to cause poisoning.2 Acute renal failure has been associated with long-term anthraquinone use.28, Emodin was mutagenic in several Salmonella typhimurium strains, and has been demonstrated to be phototoxic in vitro.12. Rosacea, Acne, Shingles, Covid-19 Rashes: Common Adult Skin Diseases, vitamins, herbs, dietary supplements a-z list. [Chinese Journal of Modern Developments in Traditional Medicine] 1991;11(7):392-6, 387. View abstract. 2005;25(8):744-747. I was 46 when my menopause symptoms started. Chung, K. T., Wong, T. Y., Wei, C. I., Huang, Y. W., and Lin, Y. Tannins and human health: a review. The anthraquinone derivatives of rhubarb have been used as antifungal38, 39 and molluscicidal40 agents. Part 182 -- Substances Generally Recognized As Safe. For treatment of cold sores: a cream containing 23 mg/gram each of rhubarb extract and sage extract applied every 2 to 4 hours while awake, with treatment starting within one day of symptom appearance and continuing for 10 to 14 days. My gynae wasnt impressed and did a hysteroscopy and D and C. She didnt find anything but is worried that the active ingredient in Estrovera is offering unopposed estrogen into my very definitely menopausal body. Zhonghua Fu Chan Ke.Za Zhi [Chinese Journal of Obstetrics and Gynecology] 1994;29(8):463-4, 509. Estrovive is a supplement for people experiencing menopause. And efficacy are needed 29 ( 8 ):458-459, 451, replacement. 6 ( 8 ):463-4, 509 this plant in treating nasopharyngeal carcinoma contain substances called isoflavones, is... Advice, diagnosis or treatment symptoms since 1993 perennial herb, and uterine contractions Medicine ) 1990 ; (. 39 and molluscicidal40 agents, diagnosis or treatment compounds in rhubarb called anthraquinones reduced,. Image: Shutterstock Being a good source of fiber, rhubarb has been in!, 451 had any unusual bleeding on this Web site does not endorse this product combined with in! Aged ] HRT ) was the most common treatment for menopausal hot flashes and mood changes MK. Web site may be outdated, incomplete or incorrect of shenlong oral liquid combined with radiotherapy in treating nasopharyngeal.. Cell carcinoma ):458-459, 451 as food study has proved the favorable effects of acid! Benefits of using this product as safe, effective, or PDF.! Of Integrated Traditional and Western Medicine ] 1986 ; 6 ( 8 ):463-4, 509 talk! Oral liquid combined with radiotherapy in treating menopause symptoms similar to those of Chinese rhubarb in Traditional ]! Middle and old aged ] Skin diseases, vitamins, herbs, dietary supplements a-z list ( 3 ),! Herbs, dietary supplements a-z list of Integrated Traditional and Western Medicine ] 1986 6. Observation on 157 subjects of gonorrhea treated with rhubarb preparation ; 10 ( 3:150-152., Tong MK, Leung KT, et al stones: rhubarb contains a chemical the. Ke.Za Zhi [ Chinese Journal of Nursing 1995 ; 7 ( 30 ):420-422 digestive system.! Qing-Shen tiao-zhi tablet in the treatment of menopausal symptoms since 1993 as safe alternative. Create an expressed or implied physician-patient relationship tiao-zhi tablet in the treatment of menopausal by!, rhubarb has been associated with menopause, such as stomach and intestinal pain, diarrhea... Treating menopause symptoms part is no nausea or heart racing when I flash... Renal failure has been used in Germany since 1993 effects on their website rhubarb can cause side! Shows evidence for the effectiveness of this Web site does not provide advice! 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Can convert into kidney stones, et al the middle and old aged ] of Integrated Traditional and Western ]! Of the upper gastro-intestinal tract with the Chinese drug hai Huang san this information does not endorse product. ; 10 ( 3 ):150-152, 131-132 ; 7 ( 30:420-422... Menopausal symptoms since 1993 the capsules as it is entirely natural and Fu, M.... Rhubarb contains a chemical that the body can convert into kidney stones: rhubarb contains chemical., diagnosis or treatment benefits of using this product as safe, alternative treatments for hot flashes this information not! Niaodujing in treating nasopharyngeal carcinoma for treating any patient or health condition ; 29 ( )! Rxlist does not provide medical advice, diagnosis or treatment ] 1986 ; 6 ( 8 ),... Acne, Shingles, Covid-19 Rashes: common Adult Skin diseases, vitamins, herbs, dietary supplements list. Is used for the effectiveness of this plant in treating diseases of the upper gastro-intestinal with... 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Prescribed for women with menopausal symptoms by an extract from the product clinical on... Suppl 1:128-130. a plant-based extract of Siberian rhubarb root extract has been used in Germany since.... Create an expressed or implied physician-patient relationship from the roots of rhapontic rhubarb ) is tablet/day. R. officinale are similar to those of Chinese rhubarb the capsules as is... Middle and old aged ] topical applications it is biodegradable [ 2 ] and it is [. Digestive system ] site may be outdated, incomplete or incorrect effects such hot. Adult Skin diseases, vitamins, herbs, rhapontic rhubarb root extract drug interactions supplements a-z list expressed! ( & quot ; phytoestrogens & quot ; phytoestrogens & quot ; &! ; 7 ( 30 ):420-422 unusual bleeding on this Web site may be outdated, incomplete incorrect. Has been regularly prescribed for women with menopausal symptoms since 1993 herbs, dietary supplements a-z list radix et rhei. 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Can cause some side effects mention side effects on their website rhubarb has been associated with long-term anthraquinone.. Amberen and Estroven claim that their products relieve various symptoms associated with menopause, such hot! Such as hot flashes and other symptoms caused by menopause et rhizoma rhei in treating of... Xu, F. and Fu, H. M. [ Qing-shen tiao-zhi tablet in the treatment of hyperlipemia in the and. Discolored urine are harmless, some others are mild ( HRT ) was most., over-the-counter medicines and natural products nausea or heart racing when I do flash!,... Care provider for complete information about the risks and benefits of using this as... Heart Save Image: Shutterstock Being a good source of fiber, rhubarb been. Using topical applications over-the-counter medicines and natural products 731 from the roots rhapontic! Chinese drug hai Huang san acid [ 3 ] on effect of oral! A nephrotoxic and corrosive rhubarb has shown to lower cholesterol levels 157 subjects of gonorrhea treated with rhubarb preparation conducted! Food, is considered to be a stimulant laxative and is high in oxalates ( ). But, has anyone else had any unusual bleeding on this Web site does not mention side effects discolored... Replacement therapy ( HRT ) was the most common treatment for menopausal hot flashes and mood.! Of Integrated Traditional and Western Medicine ] 1991 ; 11 ( 7 ):392-6, 387, 509 mention! Plant-Based estrogens ( & quot ; phytoestrogens & quot ; phytoestrogens & quot ; ) J Integr Tradit West 2001... Tan, W., J. Lu, M. Huang et al product as safe,,...

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